Referência de medicamentos
Tigecycline
Tigecycline is a medicine in the class anti bacterial. It is used for intra-abdominal infections.
- Classe do medicamento: Anti Bacterial
- Indicado para: intra-abdominal infections
Última atualização
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O conteúdo clínico desta página está disponível apenas em inglês.
Pontos-chave
- Classe do medicamento
- Anti Bacterial
- Código ATC
- J01AA12
- Formas farmacêuticas comuns
- injeção, infusão
- Concentrações comuns
- 50 mg, 50 mg/5 ml
- Interações conhecidas
- 17 (Grave: 1 · Moderada: 5 · Leve: 11)
- Nomes comerciais
- 12
- Países e mercados
- 5
Para que é usado
Como funciona
A glycylcycline antibiotic that is structurally similar to tetracycline antibiotics; inhibits bacterial protein translation by binding to 30S ribosomal subunit, and blocks entry of amino-acyl tRNA molecules in ribosome A site.
Dose habitual em adultos (resumo da bula)
Complicated Intra-abdominal Infections (Initial): 100 mg IV infusion, THEN 50 mg IV infusion q12hr for 5-14 days
Gravidez e amamentação
- Gravidez
- Unsafe Like other tetracyclines it may permanently discolour the baby's teeth and slow bone growth when given in the 2nd or 3rd trimester; skeletal delays in rats and rabbits at 1 to 5 times human exposure. UK label: do not use unless the mother's condition requires it. Prefer another antibiotic.
- Amamentação
- Safe No human milk data; poorly absorbed orally, so infant exposure is expected to be low. US label: avoid breastfeeding for courses over 3 weeks; may pump and discard during and for 9 days after. LactMed: short courses probably acceptable; watch for rash, diarrhoea or thrush.
Efeitos adversos relatados
- Vomiting
- Diarrhea
- Nausea
- Infection
- Fever
Quem deve ter cuidado
- Prescribing therapy in absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to patient
- May cause fetal harm when administered to a pregnant woman
- Increases in total bilirubin concentration, prothrombin time and transaminases reported in patients treated with tigecycline;
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Principais interações (17)
- Tigecycline + Typhoid vaccine live Major
- Bcg vaccine live + Tigecycline Moderate
- Cholera vaccine + Tigecycline Moderate
- Microbiota + Tigecycline Moderate
- Mipomersen + Tigecycline Moderate
- Sodium picosulfate / magnesium oxide / anhydrous citric acid + Tigecycline Moderate
- Balsalazide + Tigecycline Minor
- Bazedoxifene / conjugated estrogens + Tigecycline Minor
- Conjugated estrogens + Tigecycline Minor
- Desogestrel-ethinyl estradiol + Tigecycline Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Outros medicamentos desta classe
Perguntas frequentes
What is Tigecycline used for?
Tigecycline is a medicine in the class anti bacterial. It is used for Intra-abdominal infections, Pneumonia, Skin infections.
What side effects have been reported with Tigecycline?
Vomiting, Diarrhea, Nausea, Infection, Fever.
Can Tigecycline be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Like other tetracyclines it may permanently discolour the baby's teeth and slow bone growth when given in the 2nd or 3rd trimester; skeletal delays in rats and rabbits at 1 to 5 times human exposure. UK label: do not use unless the mother's condition requires it. Prefer another antibiotic. Breastfeeding: Safe. No human milk data; poorly absorbed orally, so infant exposure is expected to be low. US label: avoid breastfeeding for courses over 3 weeks; may pump and discard during and for 9 days after. LactMed: short courses probably acceptable; watch for rash, diarrhoea or thrush.
What does Tigecycline interact with?
MediHelp lists 17 known interactions for Tigecycline. Major: 1 · Moderate: 5 · Minor: 11. The most serious include Typhoid vaccine live, Bcg vaccine live, Cholera vaccine.
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