Interações medicamentosas
Tisotumab vedotin + Voriconazole
Gravidade: Moderada
Tisotumab vedotin and Voriconazole: moderate interaction.
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Resumo
Voriconazole may increase exposure to unconjugated MMAE, the cytotoxic payload released from tisotumab vedotin. This could heighten toxicities such as neutropenia, neuropathy and ocular or hepatic effects.
O que esta interação significa em palavras simples
Tisotumab vedotin and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tisotumab vedotin belongs to Oncology; Voriconazole belongs to Anti Fungals.
Por que acontece
Voriconazole inhibits CYP3A4, which metabolizes MMAE.
O que fazer
Monitor for adverse reactions such as neuropathy and neutropenia, and consider an alternative to a strong CYP3A4 inhibitor if feasible. Interrupt or reduce tisotumab vedotin if toxicity occurs.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Voriconazole
- Avanafil + Voriconazole Contraindicada
- Butabarbital + Voriconazole Contraindicada
- Carbamazepine + Voriconazole Contraindicada
- Conivaptan + Voriconazole Contraindicada
- Dihydroergotamine intranasal + Voriconazole Contraindicada
- Dihydroergotamine + Voriconazole Contraindicada
Outras interações de Tisotumab vedotin
- Chloramphenicol + Tisotumab vedotin Moderada
- Clarithromycin + Tisotumab vedotin Moderada
- Itraconazole + Tisotumab vedotin Moderada
- Ketoconazole + Tisotumab vedotin Moderada
- Mifepristone + Tisotumab vedotin Moderada
- Posaconazole + Tisotumab vedotin Moderada
Perguntas frequentes
Can I take Tisotumab vedotin with Voriconazole?
MediHelp rates the interaction as moderate. Tisotumab vedotin and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may increase exposure to unconjugated MMAE, the cytotoxic payload released from tisotumab vedotin. This could heighten toxicities such as neutropenia, neuropathy and ocular or hepatic effects.
How serious is the interaction between Tisotumab vedotin and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse reactions such as neuropathy and neutropenia, and consider an alternative to a strong CYP3A4 inhibitor if feasible. Interrupt or reduce tisotumab vedotin if toxicity occurs.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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