Interações medicamentosas
Itraconazole + Tisotumab vedotin
Gravidade: Moderada
Itraconazole and Tisotumab vedotin: moderate interaction.
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Resumo
Itraconazole may increase unconjugated MMAE exposure from tisotumab vedotin, which may worsen adverse effects such as neutropenia and neuropathy.
O que esta interação significa em palavras simples
Itraconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Tisotumab vedotin belongs to Oncology.
Por que acontece
Strong CYP3A4 inhibition reduces the metabolism of MMAE.
O que fazer
Monitor for adverse reactions such as neutropenia and neuropathy during co-therapy, and manage them by dose interruption or modification.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Itraconazole
- Alfuzosin + Itraconazole Contraindicada
- Alprazolam + Itraconazole Contraindicada
- Avanafil + Itraconazole Contraindicada
- Conivaptan + Itraconazole Contraindicada
- Dihydroergotamine intranasal + Itraconazole Contraindicada
- Dihydroergotamine + Itraconazole Contraindicada
Outras interações de Tisotumab vedotin
- Chloramphenicol + Tisotumab vedotin Moderada
- Clarithromycin + Tisotumab vedotin Moderada
- Ketoconazole + Tisotumab vedotin Moderada
- Mifepristone + Tisotumab vedotin Moderada
- Posaconazole + Tisotumab vedotin Moderada
- Tisotumab vedotin + Voriconazole Moderada
Perguntas frequentes
Can I take Itraconazole with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Itraconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase unconjugated MMAE exposure from tisotumab vedotin, which may worsen adverse effects such as neutropenia and neuropathy.
How serious is the interaction between Itraconazole and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse reactions such as neutropenia and neuropathy during co-therapy, and manage them by dose interruption or modification.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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