Interações medicamentosas
Posaconazole + Tisotumab vedotin
Gravidade: Moderada
Posaconazole and Tisotumab vedotin: moderate interaction.
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Resumo
The cytotoxic payload of tisotumab vedotin, MMAE, is metabolized by CYP3A4, so a strong inhibitor like posaconazole may increase unconjugated MMAE exposure. This could heighten toxicities such as neutropenia, neuropathy and ocular events.
O que esta interação significa em palavras simples
Posaconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Tisotumab vedotin belongs to Oncology.
Por que acontece
Strong CYP3A4 inhibition by posaconazole reduces the clearance of released MMAE.
O que fazer
Monitor closely for signs of MMAE toxicity, including blood counts and neuropathy, during concomitant use. Consider an alternative antifungal where feasible.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Posaconazole
- Artemether + Posaconazole Contraindicada
- Avanafil + Posaconazole Contraindicada
- Cobimetinib + Posaconazole Contraindicada
- Conivaptan + Posaconazole Contraindicada
- Dihydroergotamine intranasal + Posaconazole Contraindicada
- Dihydroergotamine + Posaconazole Contraindicada
Outras interações de Tisotumab vedotin
- Chloramphenicol + Tisotumab vedotin Moderada
- Clarithromycin + Tisotumab vedotin Moderada
- Itraconazole + Tisotumab vedotin Moderada
- Ketoconazole + Tisotumab vedotin Moderada
- Mifepristone + Tisotumab vedotin Moderada
- Tisotumab vedotin + Voriconazole Moderada
Perguntas frequentes
Can I take Posaconazole with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Posaconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload of tisotumab vedotin, MMAE, is metabolized by CYP3A4, so a strong inhibitor like posaconazole may increase unconjugated MMAE exposure. This could heighten toxicities such as neutropenia, neuropathy and ocular events.
How serious is the interaction between Posaconazole and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for signs of MMAE toxicity, including blood counts and neuropathy, during concomitant use. Consider an alternative antifungal where feasible.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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