藥品參考
Etranacogene dezaparvovec
Etranacogene dezaparvovec is a medicine in the class miscellaneous. It is used for hemophilia b.
- 藥物類別: Miscellaneous
- 用途: hemophilia b
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Miscellaneous
- 商品名
- 1
- 國家與市場
- 1
用途
作用方式
AAV5-based gene therapy that delivers a copy of a gene encoding the Padua variant of human coagulation Factor IX (hFIX-Padua). A single IV infusion causes cell transduction and increases circulating Factor IX activity in hemophilia B.
成人常用劑量（仿單摘要）
Hemophilia B (congenital Factor IX deficiency): 2 × 10 13 gc/kg body weight (2 mL/kg), single IV infusion after dilution with 0.9% sodium chloride, at a constant rate of 500 mL/hour (8 mL/min); can be administered only once
懷孕與哺乳
- 懷孕
- Unsafe Not intended for use in women. EU SmPC: should not be used during pregnancy; no human data or animal reproduction studies; fetal harm unknown. Males and female partners should use barrier contraception for 12 months. US: mouse mating study showed no adverse effects on fertility or fetal weight.
- 哺乳
- Unknown Not intended for administration in women.
已通報的副作用
- Blood creatine kinase increased
- Aspartate aminotransferase increased
- Alanine aminotransferase increased
- Infusion-related reactions
- Headache
- Flu-like symptoms
哪些人需要特別留意
- Hypersensitivity and infusion-related reactions, including anaphylaxis, can occur. Monitor during infusion and for at least 3 hours afterward; slow or stop the infusion if a reaction occurs.
- Hepatotoxicity with elevated transaminases can occur. Monitor ALT weekly for 3 months, then monthly for up to 1 year. Consider a corticosteroid course if ALT rises above the ULN or double baseline.
- All patients developed neutralizing anti-AAV5 antibodies after treatment.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Etranacogene dezaparvovec 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
常見問題
What is Etranacogene dezaparvovec used for?
Etranacogene dezaparvovec is a medicine in the class miscellaneous. It is used for Hemophilia b.
What side effects have been reported with Etranacogene dezaparvovec?
Blood creatine kinase increased, Aspartate aminotransferase increased, Alanine aminotransferase increased, Infusion-related reactions, Headache, Flu-like symptoms.
Can Etranacogene dezaparvovec be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Not intended for use in women. EU SmPC: should not be used during pregnancy; no human data or animal reproduction studies; fetal harm unknown. Males and female partners should use barrier contraception for 12 months. US: mouse mating study showed no adverse effects on fertility or fetal weight. Breastfeeding: Unknown. Not intended for administration in women.
What does Etranacogene dezaparvovec interact with?
MediHelp does not list a checked interaction for Etranacogene dezaparvovec yet. Always tell your pharmacist about every medicine you take.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
