藥品參考
Atidarsagene autotemcel
Atidarsagene autotemcel is a medicine in the class miscellaneous.
- 藥物類別: Miscellaneous
最後更新 來源: US FDA label
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本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Miscellaneous
- 已知交互作用
- 14 (嚴重: 11 · 中度: 3)
- 商品名
- 1
- 國家與市場
- 1
作用方式
Autologous CD34+ cells are transduced with an ARSA lentiviral vector, inserting functional ARSA cDNA copies into HSCs. After infusion the cells engraft, repopulate the hematopoietic compartment and produce ARSA enzyme, which can break down or prevent harmful sulfatide accumulation.
懷孕與哺乳
- 懷孕
- Unsafe No clinical data. Must not be given during pregnancy because of risks of the required myeloablative conditioning. Confirm a negative pregnancy test before treatment.
- 哺乳
- Unsafe No data on milk. Breastfeeding should be stopped during conditioning; follow the conditioning agent's guidance.
已通報的副作用
- Febrile neutropenia
- Stomatitis
- Respiratory tract infections
- Rash
- Device related infections
- Other viral infections
哪些人需要特別留意
- Thrombosis and thromboembolic events: a fatal cerebral infarction occurred; evaluate thrombosis risk factors before and after infusion and consider anti-thrombotic prophylaxis.
- Encephalitis: monitor for signs or symptoms after treatment; may trigger relapsing-remitting disease progression.
- Serious infection: severe Grade 3 infections occurred in 39% of children; monitor and give prophylactic antimicrobials.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (14)
- Atidarsagene autotemcel + Didanosine Major
- Atidarsagene autotemcel + Dolutegravir Major
- Atidarsagene autotemcel + Efavirenz Major
- Atidarsagene autotemcel + Emtricitabine Major
- Atidarsagene autotemcel + Lamivudine Major
- Atidarsagene autotemcel + Measles mumps and rubella vaccine Major
- Atidarsagene autotemcel + Nevirapine Major
- Atidarsagene autotemcel + Raltegravir Major
- Atidarsagene autotemcel + Stavudine Major
- Atidarsagene autotemcel + Tenofovir disoproxil Major
同類別的其他藥品
常見問題
What is Atidarsagene autotemcel used for?
Atidarsagene autotemcel is a medicine in the class miscellaneous.
What side effects have been reported with Atidarsagene autotemcel?
Febrile neutropenia, Stomatitis, Respiratory tract infections, Rash, Device related infections, Other viral infections.
Can Atidarsagene autotemcel be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No clinical data. Must not be given during pregnancy because of risks of the required myeloablative conditioning. Confirm a negative pregnancy test before treatment. Breastfeeding: Unsafe. No data on milk. Breastfeeding should be stopped during conditioning; follow the conditioning agent's guidance.
What does Atidarsagene autotemcel interact with?
MediHelp lists 14 known interactions for Atidarsagene autotemcel. Major: 11 · Moderate: 3. The most serious include Didanosine, Dolutegravir, Efavirenz.
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