藥品參考
Givinostat
Givinostat is a medicine in the class miscellaneous. It is used for duchenne muscular dystrophy.
- 藥物類別: Miscellaneous
- 用途: Duchenne Muscular Dystrophy
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Miscellaneous
- ATC 代碼
- M09AX14
- 常見劑型
- 口服懸液
- 常見規格
- 8.86 mg/ml
- 已知交互作用
- 104 (嚴重: 45 · 中度: 36 · 輕微: 23)
- 商品名
- 1
- 國家與市場
- 2
用途
作用方式
Givinostat is a histone deacetylase inhibitor. The precise mechanism by which it acts in DMD is unknown.
懷孕與哺乳
- 懷孕
- Unsafe Used for Duchenne muscular dystrophy, which affects almost only boys, so there are no pregnancy data. In rats and rabbits it lowered fetal weight and raised fetal and pup deaths and behaviour changes, some below human exposure.
- 哺乳
- Unknown No human or animal data on milk. LactMed: highly protein-bound, so milk levels are likely very low; not a reason to stop breastfeeding, but use with caution and watch the infant for diarrhoea, vomiting, bruising or bleeding.
已通報的副作用
- Diarrhea
- Abdominal pain
- Thrombocytopenia
- Nausea/vomiting
- Hypertriglyceridemia
- Pyrexia
哪些人需要特別留意
- Dose-related thrombocytopenia and myelosuppression (anemia, neutropenia); monitor blood counts every 2 weeks for first 2 months, at month 3, then every 3 months.
- Increased triglycerides; monitor at 1 month, 3 months, 6 months, then every 6 months. Discontinue if they remain elevated despite diet and dose adjustment.
- Gastrointestinal disturbances (diarrhea, nausea/vomiting, abdominal pain); consider antiemetics or antidiarrheals and replace fluids and electrolytes.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (104)
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
- Chlorpromazine + Givinostat Major
- Citalopram + Givinostat Major
- Clomipramine + Givinostat Major
- Clozapine + Givinostat Major
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Givinostat 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
在網頁版免費試用 Pro+ 14 天，無需信用卡。
常見問題
What is Givinostat used for?
Givinostat is a medicine in the class miscellaneous. It is used for Duchenne Muscular Dystrophy.
What side effects have been reported with Givinostat?
Diarrhea, Abdominal pain, Thrombocytopenia, Nausea/vomiting, Hypertriglyceridemia, Pyrexia.
Can Givinostat be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Used for Duchenne muscular dystrophy, which affects almost only boys, so there are no pregnancy data. In rats and rabbits it lowered fetal weight and raised fetal and pup deaths and behaviour changes, some below human exposure. Breastfeeding: Unknown. No human or animal data on milk. LactMed: highly protein-bound, so milk levels are likely very low; not a reason to stop breastfeeding, but use with caution and watch the infant for diarrhoea, vomiting, bruising or bleeding.
What does Givinostat interact with?
MediHelp lists 104 known interactions for Givinostat. Major: 45 · Moderate: 36 · Minor: 23. The most serious include Abiraterone, Amiodarone, Amisulpride.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
