藥物交互作用
Chlorpromazine + Givinostat
嚴重程度: 嚴重
Chlorpromazine and Givinostat: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both agents can lengthen the QTc interval, so concurrent use increases the likelihood of torsade de pointes. The risk is amplified by electrolyte abnormalities or cardiac disease.
用白話說明這項交互作用的意義
Chlorpromazine and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Givinostat belongs to Miscellaneous.
為什麼會發生
Additive QT prolongation through effects on cardiac repolarization.
處置方式
Avoid if possible. If coadministration is necessary, obtain ECGs at initiation and during use, and withhold givinostat if QTc exceeds 500 ms or rises markedly from baseline.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlorpromazine 的其他交互作用
Givinostat 的其他交互作用
常見問題
Can I take Chlorpromazine with Givinostat?
MediHelp rates the interaction as major. Chlorpromazine and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can lengthen the QTc interval, so concurrent use increases the likelihood of torsade de pointes. The risk is amplified by electrolyte abnormalities or cardiac disease.
How serious is the interaction between Chlorpromazine and Givinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If coadministration is necessary, obtain ECGs at initiation and during use, and withhold givinostat if QTc exceeds 500 ms or rises markedly from baseline.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
