藥物交互作用
Clomipramine + Givinostat
嚴重程度: 嚴重
Clomipramine and Givinostat: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both drugs can prolong the QT interval, so combining them raises the risk of torsades de pointes. Givinostat labeling recommends avoiding combination with QT-prolonging drugs.
用白話說明這項交互作用的意義
Clomipramine and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Givinostat belongs to Miscellaneous.
為什麼會發生
Additive QT prolongation.
處置方式
Avoid if possible; otherwise obtain ECGs at initiation and during use and withhold treatment if QTc becomes markedly prolonged. Correct potassium and magnesium abnormalities.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clomipramine 的其他交互作用
Givinostat 的其他交互作用
常見問題
Can I take Clomipramine with Givinostat?
MediHelp rates the interaction as major. Clomipramine and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combining them raises the risk of torsades de pointes. Givinostat labeling recommends avoiding combination with QT-prolonging drugs.
How serious is the interaction between Clomipramine and Givinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain ECGs at initiation and during use and withhold treatment if QTc becomes markedly prolonged. Correct potassium and magnesium abnormalities.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
