藥物交互作用
Amiodarone + Givinostat
嚴重程度: 嚴重
Amiodarone and Givinostat: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Givinostat can prolong the QT interval and amiodarone adds to this effect, increasing torsades de pointes risk.
用白話說明這項交互作用的意義
Amiodarone and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Givinostat belongs to Miscellaneous.
為什麼會發生
Additive QT interval prolongation.
處置方式
Avoid if possible; otherwise obtain ECGs at start and during treatment, and withhold givinostat if QTc exceeds 500 ms.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amiodarone 的其他交互作用
Givinostat 的其他交互作用
常見問題
Can I take Amiodarone with Givinostat?
MediHelp rates the interaction as major. Amiodarone and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givinostat can prolong the QT interval and amiodarone adds to this effect, increasing torsades de pointes risk.
How serious is the interaction between Amiodarone and Givinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain ECGs at start and during treatment, and withhold givinostat if QTc exceeds 500 ms.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
