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Isosorbide dinitrate

Isosorbide dinitrate is a medicine in the class cardiovascular. It is used for angina pectoris.

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僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

重點資訊

藥物類別
Cardiovascular
常見劑型
錠劑, 膠囊, 注射劑
常見規格
5 mg, 20 mg, 10 mg
已知交互作用
47 (禁忌併用: 5 · 嚴重: 2 · 中度: 14 · 輕微: 26)
商品名
31
國家與市場
4

劑型、規格與商品名稱會因國家而異。請核對您手上的產品。

用途

作用方式

Vasodilating agent (nitric oxide donor); relaxes smooth muscle via dose-dependent dilation of arterial and venous beds to reduce both preload and afterload, as well as myocardial oxygen demand; also improves coronary collateral circulation, lowering blood pressure, increasing heart rate, and causing occasional paradoxical bradycardia

成人常用劑量（仿單摘要）

Angina Pectoris (Immediate release): 5-20 mg PO q8-12hr initially; maintenance: 10-40 mg PO q8-12hr

僅摘錄仿單中第一行劑量說明；完整的劑量內容請見 App。

懷孕與哺乳

懷孕
Unknown Nitrate for angina and heart failure. No adequate human studies; embryotoxic in rabbits only at 35 to 150 times human doses. US label: use only if benefit justifies risk. Avoid maternal low blood pressure, which can reduce blood flow to the placenta.
哺乳
Unknown Not known if it passes into milk; no published data and no LactMed record. US label: use caution while breastfeeding. Discuss regular use with a doctor; a better-studied option may be preferred.

已通報的副作用

  • Headache
  • Nausea
  • Restlessness
  • Dizziness
  • Methemoglobinemia

禁忌症

  • Hypersensitivity
  • Recent use (within several days) of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, or vardenafil) may cause dangerously low hypotension; the time course of the interaction appears to be related to the PDE-5 inhibitor half-life
  • Severe anemia, shock, markedly low blood…

哪些人需要特別留意

  • Concomitant administration with guanylate stimulator riociguat
  • Severe hypotension, particularly with upright posture, may occur with even small doses; use caution in patients who may be volume depleted or who are already hypotensive
  • Treat drug-induced headache with aspirin or acetaminophen

請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。

重要交互作用 (47)

All 47 interactions, with severity and what to do

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解鎖完整頁面

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  • Dosing by age, kidney and liver function, and further dose lines
  • Paediatric dosing
  • Dosing in older adults
  • Pharmacokinetics
  • Patient counselling points
  • Food interactions
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同類別的其他藥品

常見問題

What is Isosorbide dinitrate used for?

Isosorbide dinitrate is a medicine in the class cardiovascular. It is used for Angina pectoris.

What side effects have been reported with Isosorbide dinitrate?

Headache, Nausea, Restlessness, Dizziness, Methemoglobinemia.

Can Isosorbide dinitrate be taken in pregnancy or while breastfeeding?

Pregnancy: Unknown. Nitrate for angina and heart failure. No adequate human studies; embryotoxic in rabbits only at 35 to 150 times human doses. US label: use only if benefit justifies risk. Avoid maternal low blood pressure, which can reduce blood flow to the placenta. Breastfeeding: Unknown. Not known if it passes into milk; no published data and no LactMed record. US label: use caution while breastfeeding. Discuss regular use with a doctor; a better-studied option may be preferred.

What does Isosorbide dinitrate interact with?

MediHelp lists 47 known interactions for Isosorbide dinitrate. Contraindicated: 5 · Major: 2 · Moderate: 14 · Minor: 26. The most serious include Avanafil, Riociguat, Sildenafil.

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