藥物交互作用
Amlodipine-benazepril + Isosorbide dinitrate
嚴重程度: 中度
Amlodipine-benazepril and Isosorbide dinitrate: moderate interaction.
最後更新
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摘要
Nitrates cause venous and arterial dilation, and adding amlodipine and benazepril increases the likelihood of symptomatic hypotension, dizziness or syncope. The effect is often tolerated but is more notable in older or volume-depleted patients.
用白話說明這項交互作用的意義
Amlodipine-benazepril and Isosorbide dinitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Isosorbide dinitrate belongs to Cardiovascular.
為什麼會發生
Additive vasodilation through nitric oxide-mediated smooth muscle relaxation, calcium channel blockade and reduced angiotensin II.
處置方式
Monitor blood pressure and orthostatic symptoms when starting or increasing doses. Adjust doses of antihypertensives if hypotension occurs.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amlodipine-benazepril 的其他交互作用
Isosorbide dinitrate 的其他交互作用
常見問題
Can I take Amlodipine-benazepril with Isosorbide dinitrate?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Isosorbide dinitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrates cause venous and arterial dilation, and adding amlodipine and benazepril increases the likelihood of symptomatic hypotension, dizziness or syncope. The effect is often tolerated but is more notable in older or volume-depleted patients.
How serious is the interaction between Amlodipine-benazepril and Isosorbide dinitrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing doses. Adjust doses of antihypertensives if hypotension occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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