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Lomitapide

Lomitapide is a medicine in the class cardiovascular. It is used for hypercholesterolemia.

最後更新 來源: US FDA label, EMA SmPC

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

重點資訊

藥物類別
Cardiovascular
ATC 代碼
C10AX12
常見劑型
膠囊
已知交互作用
146 (禁忌併用: 16 · 嚴重: 28 · 中度: 68 · 輕微: 34)
商品名
2
國家與市場
2

劑型、規格與商品名稱會因國家而異。請核對您手上的產品。

用途

作用方式

Binds and inhibits microsomal triglyceride transfer protein (MTP), preventing assembly of apo B-containing lipoproteins in enterocytes and hepatocytes. This inhibits chylomicron and VLDL synthesis and reduces plasma LDL-C.

成人常用劑量（仿單摘要）

HoFH (18 years and older): start 5 mg orally once daily; titrate per Table 1 (weeks 0 to 2 at 5 mg, then 10 mg, 20 mg, 40 mg); maximum 60 mg daily from week 15, based on LDL-C target, safety and tolerability

僅摘錄仿單中第一行劑量說明；完整的劑量內容請見 App。

一般服用方式

Statins are taken by mouth once a day, long term, with blood tests to check the response and liver function.

確切的劑量、服用時間與療程長短，由開立處方者及產品仿單決定；登入後，MediHelp 會顯示完整的劑量內容。

懷孕與哺乳

懷孕
Unsafe Contraindicated in pregnancy; may cause fetal harm based on animal studies. Discontinue if pregnancy is detected.
哺乳
Unsafe No data on presence in milk; breastfeeding is not recommended because of potential serious adverse reactions including hepatotoxicity.

已通報的副作用

  • Diarrhea
  • Nausea
  • Dyspepsia
  • Abdominal pain
  • Vomiting
  • Chest pain

黑框警語

  • Risk of hepatotoxicity: can raise transaminases and increase hepatic fat (steatosis), a possible risk factor for steatohepatitis and cirrhosis. Measure ALT, AST, alkaline phosphatase and bilirubin before starting, then ALT and AST regularly. Adjust dose if ALT or AST ≥3 times ULN and discontinue for clinically significant liver toxicity. Available only through the JUXTAPID REMS Program. Prescribe only for HoFH.

禁忌症

  • Pregnancy
  • Concomitant use with moderate or strong CYP3A4 inhibitors
  • Moderate or severe hepatic impairment (Child-Pugh B or C) and active liver disease, including unexplained persistent transaminase elevations

哪些人需要特別留意

  • Hepatotoxicity: transaminase elevations and hepatic steatosis; monitor liver tests before each dose increase or monthly in the first year, then at least every 3 months
  • Embryo-fetal toxicity: may cause fetal harm; negative pregnancy test before starting and effective contraception during treatment and for two weeks after
  • Reduced absorption of fat-soluble vitamins and fatty acids; daily vitamin E and essential fatty acid supplements needed

Unexplained muscle pain, tenderness or weakness while taking a statin should be reported promptly. Statins are not used in pregnancy, and some other medicines raise their levels and risk.

請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。

重要交互作用 (146)

All 146 interactions, with severity and what to do

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可開啟 Lomitapide 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。

  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Paediatric dosing
  • Dosing in older adults
  • How to give it
  • Pharmacokinetics
  • Patient counselling points
  • Food interactions
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同類別的其他藥品

常見問題

What is Lomitapide used for?

Lomitapide is a medicine in the class cardiovascular. It is used for Hypercholesterolemia.

What side effects have been reported with Lomitapide?

Diarrhea, Nausea, Dyspepsia, Abdominal pain, Vomiting, Chest pain. Serious warning: Risk of hepatotoxicity: can raise transaminases and increase hepatic fat (steatosis), a possible risk factor for steatohepatitis and cirrhosis.

Can Lomitapide be taken in pregnancy or while breastfeeding?

Pregnancy: Unsafe. Contraindicated in pregnancy; may cause fetal harm based on animal studies. Discontinue if pregnancy is detected. Breastfeeding: Unsafe. No data on presence in milk; breastfeeding is not recommended because of potential serious adverse reactions including hepatotoxicity.

What does Lomitapide interact with?

MediHelp lists 146 known interactions for Lomitapide. Contraindicated: 16 · Major: 28 · Moderate: 68 · Minor: 34. The most serious include Aprepitant, Clarithromycin, Crizotinib.

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