藥物交互作用
Fluconazole + Lomitapide
嚴重程度: 禁忌併用
Fluconazole and Lomitapide: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Lomitapide is a CYP3A4 substrate, and fluconazole, a moderate CYP3A4 inhibitor, can raise its levels several-fold. This increases the risk of hepatotoxicity and gastrointestinal adverse effects. Labeling contraindicates moderate and strong CYP3A4 inhibitors with lomitapide.
用白話說明這項交互作用的意義
Fluconazole and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluconazole belongs to Anti Fungals; Lomitapide belongs to Cardiovascular.
為什麼會發生
Fluconazole inhibits CYP3A4, reducing the metabolism of lomitapide.
處置方式
Do not combine them. If antifungal therapy is needed, use a non-CYP3A4-inhibiting alternative or hold lomitapide during a short course.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Fluconazole 的其他交互作用
Lomitapide 的其他交互作用
常見問題
Can I take Fluconazole with Lomitapide?
MediHelp rates the interaction as contraindicated. Fluconazole and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lomitapide is a CYP3A4 substrate, and fluconazole, a moderate CYP3A4 inhibitor, can raise its levels several-fold. This increases the risk of hepatotoxicity and gastrointestinal adverse effects. Labeling contraindicates moderate and strong CYP3A4 inhibitors with lomitapide.
How serious is the interaction between Fluconazole and Lomitapide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine them. If antifungal therapy is needed, use a non-CYP3A4-inhibiting alternative or hold lomitapide during a short course.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
