藥物交互作用
Erythromycin + Lomitapide
嚴重程度: 禁忌併用
Erythromycin and Lomitapide: contraindicated interaction.
最後更新
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摘要
Erythromycin, a moderate CYP3A4 inhibitor, substantially raises lomitapide exposure and increases the risk of hepatotoxicity and gastrointestinal adverse effects. Labeling contraindicates moderate and strong CYP3A4 inhibitors.
用白話說明這項交互作用的意義
Erythromycin and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Erythromycin belongs to Anti Bacterial; Lomitapide belongs to Cardiovascular.
為什麼會發生
Erythromycin inhibits CYP3A4, the main metabolic pathway of lomitapide.
處置方式
Do not coadminister; use a non-CYP3A4-inhibiting antibiotic or withhold lomitapide during a short course under specialist guidance.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Erythromycin 的其他交互作用
Lomitapide 的其他交互作用
常見問題
Can I take Erythromycin with Lomitapide?
MediHelp rates the interaction as contraindicated. Erythromycin and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin, a moderate CYP3A4 inhibitor, substantially raises lomitapide exposure and increases the risk of hepatotoxicity and gastrointestinal adverse effects. Labeling contraindicates moderate and strong CYP3A4 inhibitors.
How serious is the interaction between Erythromycin and Lomitapide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use a non-CYP3A4-inhibiting antibiotic or withhold lomitapide during a short course under specialist guidance.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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