藥物交互作用
Crizotinib + Lomitapide
嚴重程度: 禁忌併用
Crizotinib and Lomitapide: contraindicated interaction.
最後更新
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摘要
Crizotinib is a moderate CYP3A4 inhibitor and lomitapide is a sensitive CYP3A4 substrate, so exposure to lomitapide can rise markedly. This increases the risk of hepatotoxicity and gastrointestinal adverse effects.
用白話說明這項交互作用的意義
Crizotinib and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Crizotinib belongs to Oncology; Lomitapide belongs to Cardiovascular.
為什麼會發生
Crizotinib inhibits CYP3A4, reducing first-pass and systemic metabolism of lomitapide.
處置方式
Avoid the combination; labeling for lomitapide advises against moderate and strong CYP3A4 inhibitors. Use an alternative lipid-lowering strategy during crizotinib treatment.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Crizotinib 的其他交互作用
Lomitapide 的其他交互作用
常見問題
Can I take Crizotinib with Lomitapide?
MediHelp rates the interaction as contraindicated. Crizotinib and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Crizotinib is a moderate CYP3A4 inhibitor and lomitapide is a sensitive CYP3A4 substrate, so exposure to lomitapide can rise markedly. This increases the risk of hepatotoxicity and gastrointestinal adverse effects.
How serious is the interaction between Crizotinib and Lomitapide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; labeling for lomitapide advises against moderate and strong CYP3A4 inhibitors. Use an alternative lipid-lowering strategy during crizotinib treatment.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lonafarnib, Pimozide. The full list is on the Crizotinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
