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Metreleptin

Metreleptin is a medicine in the class endocrine.

  • 藥物類別: Endocrine

最後更新 來源: US FDA label

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

重點資訊

藥物類別
Endocrine
常見劑型
注射劑
常見規格
11.3 mg/2.2 ml
已知交互作用
23 (嚴重: 4 · 中度: 19)
商品名
2
國家與市場
2

劑型、規格與商品名稱會因國家而異。請核對您手上的產品。

作用方式

Leptin analog that binds to and activates the human leptin receptor (ObR), a Class I cytokine receptor that signals through the JAK/STAT pathway, replacing deficient leptin in generalized lipodystrophy.

成人常用劑量（仿單摘要）

Generalized lipodystrophy, males greater than 40 kg: start 2.5 mg subcutaneously once daily; adjust by 1.25 mg to 2.5 mg; maximum 10 mg/day

僅摘錄仿單中第一行劑量說明；完整的劑量內容請見 App。

懷孕與哺乳

懷孕
Unknown Pregnancy reports are too few to show a risk. In mice, prolonged labour, maternal deaths at birth and lower pup survival occurred from about the maximum human dose. If used in pregnancy, mix with preservative-free water (the bacteriostatic diluent has benzyl alcohol).
哺乳
Unknown No data on metreleptin in milk; natural leptin is a normal milk component. It is a protein, so little is expected to be absorbed by the infant. No LactMed record. US label: weigh breastfeeding against the mother's need.

已通報的副作用

  • Headache
  • Hypoglycemia
  • Decreased weight
  • Abdominal pain
  • Arthralgia
  • Dizziness

黑框警語

  • Neutralizing anti-metreleptin antibodies have been identified; they could inhibit endogenous leptin action and/or cause loss of efficacy. Severe infection and/or worsening metabolic control have been reported. Test for neutralizing antibodies in patients with severe infections or suspected loss of efficacy.

禁忌症

  • General obesity not associated with congenital leptin deficiency.
  • Prior severe hypersensitivity reactions to metreleptin or any product component.

哪些人需要特別留意

  • Neutralizing antibodies may inhibit endogenous leptin and cause loss of efficacy; test if severe infections or loss of efficacy occur.
  • T-cell lymphoma: consider benefits and risks in patients with acquired generalized lipodystrophy or significant hematologic abnormalities.
  • Hypoglycemia with concomitant insulin or insulin secretagogues; monitor blood glucose.

請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。

重要交互作用 (23)

All 23 interactions, with severity and what to do

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解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可開啟 Metreleptin 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。

  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Paediatric dosing
  • Dosing in older adults
  • How to give it
  • Pharmacokinetics
  • Patient counselling points
  • Food interactions
  • IV preparation and dilution
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常見問題

What is Metreleptin used for?

Metreleptin is a medicine in the class endocrine.

What side effects have been reported with Metreleptin?

Headache, Hypoglycemia, Decreased weight, Abdominal pain, Arthralgia, Dizziness. Serious warning: Neutralizing anti-metreleptin antibodies have been identified; they could inhibit endogenous leptin action and/or cause loss of efficacy.

Can Metreleptin be taken in pregnancy or while breastfeeding?

Pregnancy: Unknown. Pregnancy reports are too few to show a risk. In mice, prolonged labour, maternal deaths at birth and lower pup survival occurred from about the maximum human dose. If used in pregnancy, mix with preservative-free water (the bacteriostatic diluent has benzyl alcohol). Breastfeeding: Unknown. No data on metreleptin in milk; natural leptin is a normal milk component. It is a protein, so little is expected to be absorbed by the infant. No LactMed record. US label: weigh breastfeeding against the mother's need.

What does Metreleptin interact with?

MediHelp lists 23 known interactions for Metreleptin. Major: 4 · Moderate: 19. The most serious include Insulin aspart, Insulin glargine, Insulin glargine-lixisenatide.

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