藥物交互作用
Cyclosporin + Metreleptin
嚴重程度: 中度
Cyclosporin and Metreleptin: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Metreleptin may change cyclosporine metabolism via effects on CYP450 enzymes, leading to unpredictable blood levels. Subtherapeutic or toxic levels may result.
用白話說明這項交互作用的意義
Cyclosporin and Metreleptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Metreleptin belongs to Endocrine.
為什麼會發生
Leptin may alter CYP450 expression, and metabolic improvement may change cyclosporine clearance.
處置方式
Monitor cyclosporine trough concentrations and renal function when starting, adjusting or stopping metreleptin, and adjust the dose.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Metreleptin 的其他交互作用
Cyclosporin 的其他交互作用
常見問題
Can I take Cyclosporin with Metreleptin?
MediHelp rates the interaction as moderate. Cyclosporin and Metreleptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metreleptin may change cyclosporine metabolism via effects on CYP450 enzymes, leading to unpredictable blood levels. Subtherapeutic or toxic levels may result.
How serious is the interaction between Cyclosporin and Metreleptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations and renal function when starting, adjusting or stopping metreleptin, and adjust the dose.
What other medicines interact with Metreleptin?
MediHelp also lists interactions of Metreleptin with, for example, Insulin aspart, Insulin glargine-lixisenatide, Insulin glargine. The full list is on the Metreleptin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
