藥物交互作用
Brexpiprazole + Oliceridine
嚴重程度: 嚴重
Brexpiprazole and Oliceridine: major interaction.
最後更新 來源: EMA SmPC
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摘要
Oliceridine is an intravenous opioid and brexpiprazole is a sedating antipsychotic, so together they can cause profound sedation, hypotension and respiratory depression. Opioid labeling warns of this with other CNS depressants.
用白話說明這項交互作用的意義
Brexpiprazole and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brexpiprazole belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
為什麼會發生
Additive CNS and respiratory depression from opioid agonism and antipsychotic sedative effects.
處置方式
Use the lowest effective oliceridine dose and shortest duration, and monitor sedation, respiratory rate and oxygen saturation. Reduce doses if excessive sedation occurs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Brexpiprazole 的其他交互作用
Oliceridine 的其他交互作用
常見問題
Can I take Brexpiprazole with Oliceridine?
MediHelp rates the interaction as major. Brexpiprazole and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oliceridine is an intravenous opioid and brexpiprazole is a sedating antipsychotic, so together they can cause profound sedation, hypotension and respiratory depression. Opioid labeling warns of this with other CNS depressants.
How serious is the interaction between Brexpiprazole and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective oliceridine dose and shortest duration, and monitor sedation, respiratory rate and oxygen saturation. Reduce doses if excessive sedation occurs.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
