藥物交互作用
Efavirenz + Regorafenib
嚴重程度: 嚴重
Efavirenz and Regorafenib: major interaction.
最後更新 來源: US FDA label
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摘要
Efavirenz is an inducer of CYP3A4 and may lower regorafenib exposure while changing the ratio of its active metabolites. This may reduce antitumour efficacy and alter the toxicity profile.
用白話說明這項交互作用的意義
Efavirenz and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Efavirenz belongs to Anti Virals; Regorafenib belongs to Oncology.
為什麼會發生
Efavirenz induces CYP3A4, accelerating regorafenib metabolism.
處置方式
Avoid concomitant use and choose an antiretroviral without enzyme-inducing effects, such as an integrase inhibitor-based regimen. If unavoidable, monitor tumour response and adverse effects closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Efavirenz 的其他交互作用
Regorafenib 的其他交互作用
常見問題
Can I take Efavirenz with Regorafenib?
MediHelp rates the interaction as major. Efavirenz and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Efavirenz is an inducer of CYP3A4 and may lower regorafenib exposure while changing the ratio of its active metabolites. This may reduce antitumour efficacy and alter the toxicity profile.
How serious is the interaction between Efavirenz and Regorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose an antiretroviral without enzyme-inducing effects, such as an integrase inhibitor-based regimen. If unavoidable, monitor tumour response and adverse effects closely.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
