藥品參考
Riociguat
Riociguat is a medicine in the class cardiovascular. It is used for pulmonary hypertension.
- 藥物類別: Cardiovascular
- 用途: pulmonary hypertension
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Cardiovascular
- ATC 代碼
- C02KX05
- 常見劑型
- 錠劑
- 常見規格
- 0.5 mg
- 已知交互作用
- 79 (禁忌併用: 9 · 嚴重: 9 · 中度: 49 · 輕微: 12)
- 商品名
- 3
- 國家與市場
- 3
用途
作用方式
Stimulator of soluble guanylate cyclase (sGC). It sensitizes sGC to endogenous nitric oxide and also directly stimulates sGC independently of NO, increasing cGMP and causing vasodilation.
成人常用劑量（仿單摘要）
CTEPH or PAH: start 1 mg orally three times a day (consider 0.5 mg three times a day if hypotension may not be tolerated); if systolic BP stays above 95 mmHg with no hypotension symptoms, increase by 0.5 mg three times a day no sooner than every 2 weeks; maximum 2.5 mg three times a day
懷孕與哺乳
- 懷孕
- Unsafe Contraindicated in pregnancy; animal studies show fetal harm including birth defects, fetal death and miscarriage. Human data are limited.
- 哺乳
- Unsafe No human milk data; present in rat milk. Advise not to breastfeed because of risk of hypotension in infants.
已通報的副作用
- Headache
- Dyspepsia and gastritis
- Dizziness
- Nausea
- Diarrhea
- Hypotension
黑框警語
- Embryo-fetal toxicity: contraindicated in pregnancy because it may cause fetal harm based on animal data. Exclude pregnancy before treatment. Use effective contraception before, during and for one month after treatment. If pregnancy is detected, discontinue as soon as possible.
禁忌症
- Pregnancy
- Concomitant nitrates or nitric oxide donors in any form
- Concomitant PDE inhibitors (specific PDE-5 inhibitors and nonspecific such as dipyridamole or theophylline)
哪些人需要特別留意
- Hypotension: reduces blood pressure; consider risk in hypovolemia, severe left ventricular outflow obstruction, resting hypotension, autonomic dysfunction, antihypertensives or strong CYP/P-gp/BCRP inhibitors; consider dose reduction.
- Bleeding: serious bleeding occurred in 2.4% of patients on Adempas vs 0% placebo, including serious hemoptysis in 1%.
- Pulmonary veno-occlusive disease: not recommended; if pulmonary edema occurs, consider PVOD and discontinue if confirmed.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (79)
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
- Riociguat + Tadalafil Contraindicated
- Riociguat + Theophylline Contraindicated
- Riociguat + Vardenafil Contraindicated
- Apalutamide + Riociguat Major
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Riociguat 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
在網頁版免費試用 Pro+ 14 天，無需信用卡。
常見問題
What is Riociguat used for?
Riociguat is a medicine in the class cardiovascular. It is used for Pulmonary hypertension.
What side effects have been reported with Riociguat?
Headache, Dyspepsia and gastritis, Dizziness, Nausea, Diarrhea, Hypotension. Serious warning: Embryo-fetal toxicity: contraindicated in pregnancy because it may cause fetal harm based on animal data.
Can Riociguat be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated in pregnancy; animal studies show fetal harm including birth defects, fetal death and miscarriage. Human data are limited. Breastfeeding: Unsafe. No human milk data; present in rat milk. Advise not to breastfeed because of risk of hypotension in infants.
What does Riociguat interact with?
MediHelp lists 79 known interactions for Riociguat. Contraindicated: 9 · Major: 9 · Moderate: 49 · Minor: 12. The most serious include Avanafil, Dipyridamole, Isosorbide dinitrate.
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