藥物交互作用
Riociguat + Vardenafil
嚴重程度: 禁忌併用
Riociguat and Vardenafil: contraindicated interaction.
最後更新
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摘要
Riociguat stimulates soluble guanylate cyclase and vardenafil prevents cGMP degradation, which together produce severe additive hypotension. Labeling prohibits PDE5 inhibitors with riociguat.
用白話說明這項交互作用的意義
Riociguat and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Riociguat belongs to Cardiovascular; Vardenafil belongs to Genitourinary.
為什麼會發生
Increased cGMP synthesis plus reduced cGMP breakdown cause additive vasodilation.
處置方式
Do not combine. Use a different treatment for erectile dysfunction in patients on riociguat.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Vardenafil 的其他交互作用
Riociguat 的其他交互作用
常見問題
Can I take Riociguat with Vardenafil?
MediHelp rates the interaction as contraindicated. Riociguat and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Riociguat stimulates soluble guanylate cyclase and vardenafil prevents cGMP degradation, which together produce severe additive hypotension. Labeling prohibits PDE5 inhibitors with riociguat.
How serious is the interaction between Riociguat and Vardenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a different treatment for erectile dysfunction in patients on riociguat.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
