藥物交互作用
Deutetrabenazine + Safinamide
嚴重程度: 禁忌併用
Deutetrabenazine and Safinamide: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Deutetrabenazine is contraindicated with MAO inhibitors and within 14 days of stopping them. The combination may produce hypertension and excess sympathetic activity.
用白話說明這項交互作用的意義
Deutetrabenazine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Deutetrabenazine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
為什麼會發生
Vesicular monoamine depletion by deutetrabenazine together with MAO inhibition causes unstable catecholamine effects.
處置方式
Do not combine and keep a 14-day interval after stopping the MAO inhibitor. Consider other therapy for the movement disorder.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Safinamide 的其他交互作用
Deutetrabenazine 的其他交互作用
常見問題
Can I take Deutetrabenazine with Safinamide?
MediHelp rates the interaction as contraindicated. Deutetrabenazine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine is contraindicated with MAO inhibitors and within 14 days of stopping them. The combination may produce hypertension and excess sympathetic activity.
How serious is the interaction between Deutetrabenazine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine and keep a 14-day interval after stopping the MAO inhibitor. Consider other therapy for the movement disorder.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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