藥物交互作用
Losartan + Selexipag
嚴重程度: 中度
Losartan and Selexipag: moderate interaction.
最後更新
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摘要
Selexipag is cleared by CYP2C8 to its active metabolite, and inhibitors of this enzyme may increase exposure. Higher exposure may cause more headache, diarrhea, jaw pain, and hypotension.
用白話說明這項交互作用的意義
Losartan and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Losartan belongs to Cardiovascular; Selexipag belongs to Cardiovascular.
為什麼會發生
Possible inhibition of CYP2C8-mediated selexipag metabolism.
處置方式
Monitor for prostacyclin-related adverse effects and blood pressure. Follow selexipag labeling on dosing frequency with moderate CYP2C8 inhibitors.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Losartan 的其他交互作用
Selexipag 的其他交互作用
常見問題
Can I take Losartan with Selexipag?
MediHelp rates the interaction as moderate. Losartan and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selexipag is cleared by CYP2C8 to its active metabolite, and inhibitors of this enzyme may increase exposure. Higher exposure may cause more headache, diarrhea, jaw pain, and hypotension.
How serious is the interaction between Losartan and Selexipag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for prostacyclin-related adverse effects and blood pressure. Follow selexipag labeling on dosing frequency with moderate CYP2C8 inhibitors.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
