藥物交互作用
Eltrombopag + Selexipag
嚴重程度: 中度
Eltrombopag and Selexipag: moderate interaction.
最後更新
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摘要
Eltrombopag inhibits BCRP, and selexipag is a BCRP substrate, so selexipag exposure may increase. This could lead to more prostacyclin-type effects such as headache, flushing, diarrhea and hypotension.
用白話說明這項交互作用的意義
Eltrombopag and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Selexipag belongs to Cardiovascular.
為什麼會發生
Eltrombopag inhibits the efflux transporter BCRP (ABCG2), reducing selexipag clearance.
處置方式
Monitor for selexipag adverse effects and reduce the dose or slow titration if poorly tolerated.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Eltrombopag 的其他交互作用
Selexipag 的其他交互作用
常見問題
Can I take Eltrombopag with Selexipag?
MediHelp rates the interaction as moderate. Eltrombopag and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eltrombopag inhibits BCRP, and selexipag is a BCRP substrate, so selexipag exposure may increase. This could lead to more prostacyclin-type effects such as headache, flushing, diarrhea and hypotension.
How serious is the interaction between Eltrombopag and Selexipag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for selexipag adverse effects and reduce the dose or slow titration if poorly tolerated.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
