藥品參考
Sodium oxybate
Sodium oxybate is a medicine in the class central nervous system. It is used for narcolepsy.
- 藥物類別: Central Nervous System
- 用途: narcolepsy
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Central Nervous System
- ATC 代碼
- N07XX04
- 常見劑型
- 口服懸液, 溶液
- 常見規格
- 50%
- 已知交互作用
- 99 (禁忌併用: 17 · 嚴重: 79 · 中度: 3)
- 商品名
- 3
- 國家與市場
- 2
用途
作用方式
CNS depressant. Mechanism in narcolepsy is unknown. It is the sodium salt of GHB, a metabolite of GABA; therapeutic effects are hypothesized to be mediated through GABA B actions at noradrenergic, dopaminergic and thalamocortical neurons.
成人常用劑量（仿單摘要）
Narcolepsy (cataplexy or EDS): start 4.5 g per night orally in two divided doses (2.25 g at bedtime and 2.25 g 2.5 to 4 hours later); increase by 1.5 g per night at weekly intervals; effective range 6 g to 9 g per night; doses higher than 9 g per night not studied.
懷孕與哺乳
- 懷孕
- Unknown No adequate human data. Rat pre/postnatal study showed increased stillbirths and decreased offspring viability and growth at a clinically relevant dose.
- 哺乳
- Unknown GHB is excreted in human milk; insufficient information on infant risk. Weigh breastfeeding benefits against maternal need.
已通報的副作用
- Nausea
- Dizziness
- Vomiting
- Somnolence
- Enuresis
- Tremor
黑框警語
- CNS depression: Xyrem is a CNS depressant; obtundation and clinically significant respiratory depression occurred in adults at recommended doses.
禁忌症
- Combination with sedative hypnotics.
- Combination with alcohol.
- Succinic semialdehyde dehydrogenase deficiency.
哪些人需要特別留意
- Concurrent use with other CNS depressants may increase risk of respiratory depression, hypotension, profound sedation, syncope and death; consider dose reduction or discontinuation.
- No hazardous activities requiring mental alertness for at least 6 hours after dosing.
- May impair respiratory drive; increased central apneas and desaturation observed in adults and children.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (99)
- Alprazolam + Sodium oxybate Contraindicated
- Amobarbital + Sodium oxybate Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Eszopiclone + Sodium oxybate Contraindicated
- Methadone + Sodium oxybate Contraindicated
- Midazolam + Sodium oxybate Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Sodium oxybate 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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常見問題
What is Sodium oxybate used for?
Sodium oxybate is a medicine in the class central nervous system. It is used for Narcolepsy.
What side effects have been reported with Sodium oxybate?
Nausea, Dizziness, Vomiting, Somnolence, Enuresis, Tremor. Serious warning: CNS depression: Xyrem is a CNS depressant; obtundation and clinically significant respiratory depression occurred in adults at recommended doses.
Can Sodium oxybate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human data. Rat pre/postnatal study showed increased stillbirths and decreased offspring viability and growth at a clinically relevant dose. Breastfeeding: Unknown. GHB is excreted in human milk; insufficient information on infant risk. Weigh breastfeeding benefits against maternal need.
What does Sodium oxybate interact with?
MediHelp lists 99 known interactions for Sodium oxybate. Contraindicated: 17 · Major: 79 · Moderate: 3. The most serious include Alprazolam, Amobarbital, Butorphanol.
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