藥物交互作用
Chloral hydrate + Sodium oxybate
嚴重程度: 禁忌併用
Chloral hydrate and Sodium oxybate: contraindicated interaction.
最後更新
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摘要
Both agents depress the central nervous system, and together they can cause profound sedation, respiratory depression, coma, or death. Oxybate labeling prohibits use with sedative hypnotics.
用白話說明這項交互作用的意義
Chloral hydrate and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Chloral hydrate belongs to Central Nervous System; Sodium oxybate belongs to Central Nervous System.
為什麼會發生
Additive CNS and respiratory depression through pharmacodynamic synergism (GABAergic sedative plus GHB-receptor and GABA-B agonism).
處置方式
Do not combine; stop chloral hydrate or use a non-sedating alternative before starting sodium oxybate.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Chloral hydrate 的其他交互作用
Sodium oxybate 的其他交互作用
常見問題
Can I take Chloral hydrate with Sodium oxybate?
MediHelp rates the interaction as contraindicated. Chloral hydrate and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents depress the central nervous system, and together they can cause profound sedation, respiratory depression, coma, or death. Oxybate labeling prohibits use with sedative hypnotics.
How serious is the interaction between Chloral hydrate and Sodium oxybate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop chloral hydrate or use a non-sedating alternative before starting sodium oxybate.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Chloral hydrate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
