藥品參考
Stavudine
Stavudine is a medicine in the class anti virals. It is used for hiv.
- 藥物類別: Anti Virals
- 用途: hiv
最後更新
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本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Anti Virals
- 常見劑型
- 膠囊
- 常見規格
- 40 mg, 15 mg, 20 mg
- 已知交互作用
- 18 (禁忌併用: 4 · 嚴重: 6 · 中度: 7 · 輕微: 1)
- 商品名
- 5
- 國家與市場
- 1
用途
作用方式
Nucleoside Reverse Transcriptase Inhibitor (NRTI); thymidine analog that interferes with HIV viral DNA dependent DNA polymerase and inhibits viral replication
成人常用劑量（仿單摘要）
HIV Infection (<60 kg): 30 mg PO q12hr
懷孕與哺乳
- 懷孕
- Unsafe Fatal lactic acidosis has occurred in pregnant women given stavudine with didanosine (a contraindicated combination). Registry data are too few to judge birth-defect risk. Current HIV guidelines no longer recommend stavudine; switch to a preferred regimen.
- 哺乳
- Unsafe Passes into milk. US label: do not breastfeed (HIV transmission, viral resistance, infant side effects); LactMed: not a recommended drug during breastfeeding. Follow national HIV guidance; switch to a recommended regimen.
已通報的副作用
- Headache
- Insomnia
- Malaise
- Anxiety
- Chills/fever
禁忌症
- Hypersensitivity
- Coadministration with didanosine
哪些人需要特別留意
- Risk of potentially fatal pancreatitis when used with didanosine
- Decrease dose in renal impairment
- Severe motor weakness reported
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (18)
- Didanosine + Stavudine Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Stavudine Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Stavudine Major
- Betibeglogene autotemcel + Stavudine Major
- Elivaldogene autotemcel + Stavudine Major
- Hydroxyurea + Stavudine Major
- Lovotibeglogene autotemcel + Stavudine Major
- Ribavirin + Stavudine Major
同類別的其他藥品
常見問題
What is Stavudine used for?
Stavudine is a medicine in the class anti virals. It is used for HIV.
What side effects have been reported with Stavudine?
Headache, Insomnia, Malaise, Anxiety, Chills/fever.
Can Stavudine be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Fatal lactic acidosis has occurred in pregnant women given stavudine with didanosine (a contraindicated combination). Registry data are too few to judge birth-defect risk. Current HIV guidelines no longer recommend stavudine; switch to a preferred regimen. Breastfeeding: Unsafe. Passes into milk. US label: do not breastfeed (HIV transmission, viral resistance, infant side effects); LactMed: not a recommended drug during breastfeeding. Follow national HIV guidance; switch to a recommended regimen.
What does Stavudine interact with?
MediHelp lists 18 known interactions for Stavudine. Contraindicated: 4 · Major: 6 · Moderate: 7 · Minor: 1. The most serious include Didanosine, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide.
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