藥物交互作用
Didanosine + Stavudine
嚴重程度: 禁忌併用
Didanosine and Stavudine: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Combining these two nucleoside analogues markedly raises the risk of pancreatitis, peripheral neuropathy and lactic acidosis with hepatic steatosis. Fatal cases have been reported, particularly in pregnant women.
用白話說明這項交互作用的意義
Didanosine and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Didanosine belongs to Anti Virals; Stavudine belongs to Anti Virals.
為什麼會發生
Additive mitochondrial toxicity from inhibition of mitochondrial DNA polymerase gamma.
處置方式
Avoid the combination and use a safer nucleoside backbone. If already on it, switch promptly and monitor for symptoms of pancreatitis, neuropathy and lactic acidosis.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Stavudine 的其他交互作用
Didanosine 的其他交互作用
常見問題
Can I take Didanosine with Stavudine?
MediHelp rates the interaction as contraindicated. Didanosine and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining these two nucleoside analogues markedly raises the risk of pancreatitis, peripheral neuropathy and lactic acidosis with hepatic steatosis. Fatal cases have been reported, particularly in pregnant women.
How serious is the interaction between Didanosine and Stavudine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a safer nucleoside backbone. If already on it, switch promptly and monitor for symptoms of pancreatitis, neuropathy and lactic acidosis.
What other medicines interact with Stavudine?
MediHelp also lists interactions of Stavudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Zidovudine. The full list is on the Stavudine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
