藥物交互作用
Stavudine + Zidovudine
嚴重程度: 禁忌併用
Stavudine and Zidovudine: contraindicated interaction.
最後更新
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摘要
Zidovudine and stavudine compete for intracellular phosphorylation by thymidine kinase, reducing stavudine activation and antiviral efficacy. The combination is antagonistic and should not be used.
用白話說明這項交互作用的意義
Stavudine and Zidovudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Stavudine belongs to Anti Virals; Zidovudine belongs to Anti Virals.
為什麼會發生
Competitive inhibition of thymidine kinase phosphorylation, reducing stavudine triphosphate formation.
處置方式
Do not combine. Use a regimen with only one thymidine analogue, or preferably newer NRTIs.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Zidovudine 的其他交互作用
Stavudine 的其他交互作用
常見問題
Can I take Stavudine with Zidovudine?
MediHelp rates the interaction as contraindicated. Stavudine and Zidovudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Zidovudine and stavudine compete for intracellular phosphorylation by thymidine kinase, reducing stavudine activation and antiviral efficacy. The combination is antagonistic and should not be used.
How serious is the interaction between Stavudine and Zidovudine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a regimen with only one thymidine analogue, or preferably newer NRTIs.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Atidarsagene autotemcel, Betibeglogene autotemcel. The full list is on the Zidovudine page.
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