藥品參考
Telotristat etiprate
Telotristat etiprate is a medicine in the class gastrointestinal tract. It is used for diarrhea.
- 藥物類別: Gastrointestinal Tract
- 用途: diarrhea
最後更新 來源: EMA SmPC
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Gastrointestinal Tract
- 已知交互作用
- 12 (中度: 10 · 輕微: 2)
- 商品名
- 1
- 國家與市場
- 1
用途
作用方式
Telotristat ethyl and its active metabolite telotristat inhibit L-tryptophan hydroxylases (TPH1 and TPH2), the rate-limiting steps in serotonin biosynthesis. By inhibiting peripheral TPH1 it reduces serotonin production and eases carcinoid syndrome symptoms.
成人常用劑量（仿單摘要）
Carcinoid syndrome diarrhoea (with somatostatin analogue therapy, adults inadequately controlled by SSA): 250 mg orally three times daily; higher doses not recommended; reassess benefit if no response within 12 weeks
懷孕與哺乳
- 懷孕
- Unknown No human data. No fetal effects in rats at 9 times human exposure; in rabbits fetal loss only with maternal toxicity (15 times), and more early pup deaths in rats at 5 times. EU: not recommended in pregnancy or without contraception. Avoid; use adequate contraception.
- 哺乳
- Unknown No human or animal milk data; no LactMed record. EU label: should not be used while breastfeeding (risk cannot be excluded); US label: weigh benefits and watch the infant for constipation. Avoid if possible.
已通報的副作用
- Abdominal pain
- Gamma-glutamyl transferase increased
- Fatigue
- Abdominal distension
- Flatulence
- Constipation
禁忌症
- Hypersensitivity to the active substance or to any excipients.
哪些人需要特別留意
- Hepatic enzyme elevations: monitor liver enzymes before and during therapy as clinically indicated; discontinue if liver injury is suspected and do not resume unless another cause is found.
- Constipation: telotristat reduces bowel movement frequency; monitor for constipation and re-evaluate therapy if it develops.
- Depressive disorders: depression, depressed mood and decreased interest reported; patients should report symptoms.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (12)
- Bupropion + Telotristat etiprate Moderate
- Capecitabine + Telotristat etiprate Moderate
- Everolimus + Telotristat etiprate Moderate
- Flutamide + Telotristat etiprate Moderate
- Irinotecan + Telotristat etiprate Moderate
- Midazolam + Telotristat etiprate Moderate
- Octreotide + Telotristat etiprate Moderate
- Prasugrel + Telotristat etiprate Moderate
- Simvastatin + Telotristat etiprate Moderate
- Sodium valproate + Telotristat etiprate Moderate
常見問題
What is Telotristat etiprate used for?
Telotristat etiprate is a medicine in the class gastrointestinal tract. It is used for Diarrhea.
What side effects have been reported with Telotristat etiprate?
Abdominal pain, Gamma-glutamyl transferase increased, Fatigue, Abdominal distension, Flatulence, Constipation.
Can Telotristat etiprate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data. No fetal effects in rats at 9 times human exposure; in rabbits fetal loss only with maternal toxicity (15 times), and more early pup deaths in rats at 5 times. EU: not recommended in pregnancy or without contraception. Avoid; use adequate contraception. Breastfeeding: Unknown. No human or animal milk data; no LactMed record. EU label: should not be used while breastfeeding (risk cannot be excluded); US label: weigh benefits and watch the infant for constipation. Avoid if possible.
What does Telotristat etiprate interact with?
MediHelp lists 12 known interactions for Telotristat etiprate. Moderate: 10 · Minor: 2. The most serious include Bupropion, Capecitabine, Everolimus.
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