藥物交互作用
Capecitabine + Telotristat etiprate
嚴重程度: 中度
Capecitabine and Telotristat etiprate: moderate interaction.
最後更新
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摘要
Telotristat etiprate is a prodrug and its metabolites may affect carboxylesterase 2 (CES2) activity. Capecitabine depends on carboxylesterase for conversion to its active form, so exposure and effect could change. The clinical significance is not well established.
用白話說明這項交互作用的意義
Capecitabine and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Telotristat etiprate belongs to Gastrointestinal Tract.
為什麼會發生
Possible modulation of CES2-mediated metabolism of capecitabine; the effect has not been clearly established clinically.
處置方式
Monitor for reduced capecitabine efficacy and for fluoropyrimidine toxicity such as diarrhea, hand-foot syndrome and myelosuppression when starting or stopping telotristat.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Telotristat etiprate 的其他交互作用
Capecitabine 的其他交互作用
常見問題
Can I take Capecitabine with Telotristat etiprate?
MediHelp rates the interaction as moderate. Capecitabine and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat etiprate is a prodrug and its metabolites may affect carboxylesterase 2 (CES2) activity. Capecitabine depends on carboxylesterase for conversion to its active form, so exposure and effect could change. The clinical significance is not well established.
How serious is the interaction between Capecitabine and Telotristat etiprate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced capecitabine efficacy and for fluoropyrimidine toxicity such as diarrhea, hand-foot syndrome and myelosuppression when starting or stopping telotristat.
What other medicines interact with Telotristat etiprate?
MediHelp also lists interactions of Telotristat etiprate with, for example, Bupropion, Everolimus, Flutamide. The full list is on the Telotristat etiprate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
