藥品參考
Tiratricol
Tiratricol is a medicine in the class endocrine.
- 藥物類別: Endocrine
最後更新 來源: EMA SmPC
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Endocrine
- ATC 代碼
- H03AA04
- 已知交互作用
- 13 (嚴重: 1 · 中度: 12)
- 商品名
- 1
- 國家與市場
- 1
作用方式
Tiratricol is a naturally circulating metabolite of T3 that binds with high affinity to thyroid hormone receptors TRα and TRβ and has T3-like effects. It can enter MCT8-dependent cells without a functioning MCT8 transporter, so it can replace T3 in MCT8-dependent tissues.
成人常用劑量（仿單摘要）
Peripheral thyrotoxicosis in MCT8 deficiency, body weight 10 kg or above (adults, adolescents, children, infants): start 350 micrograms daily orally or via feeding tube in 1 to 3 doses; increase by 350 micrograms every two weeks to maintenance; target serum T3 below midpoint of normal range for age.
懷孕與哺乳
- 懷孕
- Unsafe Contraindicated in pregnancy (EU): it crosses the placenta and animal studies showed reproductive toxicity. Women who could become pregnant must use effective contraception. Used for MCT8 deficiency, which almost only affects males.
- 哺乳
- Unknown Not known if it passes into milk; no LactMed record. EU label: risk cannot be excluded; decide whether to stop breastfeeding or the drug. e-lactancia: limited compatibility (a thyroid hormone analogue); prefer a safer option or stop breastfeeding.
已通報的副作用
- Hyperhidrosis
- Diarrhoea
- Irritability
- Anxiety
- Nightmares
禁忌症
- Hypersensitivity to the active substance or any excipient.
- Hyperthyroidism for reasons other than MCT8 deficiency (e.g. Graves' disease).
- Pregnancy.
哪些人需要特別留意
- Hypermetabolic signs and symptoms (hyperhidrosis, irritability, anxiety, insomnia, tachycardia, diarrhoea etc.) may occur at initiation or during titration; reduce dose if not resolved within 2 weeks.
- Use caution during titration in patients with cardiac disease.
- Tiratricol cross-reacts with T3 in immunoassays, giving unreliable results; LC/MS/MS is recommended.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (13)
- Levothyroxine + Tiratricol Major
- Calcium + Tiratricol Moderate
- Carbamazepine + Tiratricol Moderate
- Carbimazole + Tiratricol Moderate
- Charcoal + Tiratricol Moderate
- Chloroquine + Tiratricol Moderate
- Cholestyramine + Tiratricol Moderate
- Iron + Tiratricol Moderate
- Orlistat + Tiratricol Moderate
- Phenytoin + Tiratricol Moderate
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Tiratricol 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
常見問題
What is Tiratricol used for?
Tiratricol is a medicine in the class endocrine.
What side effects have been reported with Tiratricol?
Hyperhidrosis, Diarrhoea, Irritability, Anxiety, Nightmares.
Can Tiratricol be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated in pregnancy (EU): it crosses the placenta and animal studies showed reproductive toxicity. Women who could become pregnant must use effective contraception. Used for MCT8 deficiency, which almost only affects males. Breastfeeding: Unknown. Not known if it passes into milk; no LactMed record. EU label: risk cannot be excluded; decide whether to stop breastfeeding or the drug. e-lactancia: limited compatibility (a thyroid hormone analogue); prefer a safer option or stop breastfeeding.
What does Tiratricol interact with?
MediHelp lists 13 known interactions for Tiratricol. Major: 1 · Moderate: 12. The most serious include Levothyroxine, Calcium, Carbamazepine.
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