藥品參考
Valrubicin
Valrubicin is a medicine in the class oncology. It is used for bladder cancer.
- 藥物類別: Oncology
- 用途: bladder cancer
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Oncology
- 常見劑型
- 溶液
- 常見規格
- 40 mg/ml
- 商品名
- 1
- 國家與市場
- 1
用途
作用方式
Anthracycline that inhibits incorporation of nucleosides into nucleic acids, causes chromosomal damage and arrests the cell cycle in G2. Its metabolites interfere with the DNA breaking-resealing action of DNA topoisomerase II.
成人常用劑量（仿單摘要）
BCG-refractory carcinoma in situ of the urinary bladder: 800 mg, intravesical, once a week for six weeks; delay at least two weeks after transurethral resection and/or fulguration
懷孕與哺乳
- 懷孕
- Unsafe Can cause fetal harm; no human data. In rats, IV valrubicin caused embryo-fetal malformations and increased resorptions.
- 哺乳
- Unsafe No data on milk presence; advise not to breastfeed during treatment and for 2 weeks after the final dose.
已通報的副作用
- Urinary frequency
- Dysuria
- Urinary urgency
- Bladder spasm
- Hematuria
- Bladder pain
禁忌症
- Perforated bladder or compromised bladder mucosa
- Known hypersensitivity to anthracyclines or polyoxyl castor oil
- Active urinary tract infection
哪些人需要特別留意
- Delaying cystectomy can lead to metastatic bladder cancer, which is lethal; reconsider cystectomy if no complete response after 3 months or if CIS recurs.
- Evaluate the bladder before instillation; do not give to patients with perforated bladder or compromised mucosa, as systemic exposure and severe leukopenia/neutropenia can occur.
- Use with caution in severe irritable bladder symptoms; bladder spasm and spontaneous discharge of instillate may occur; clamping the catheter is not advised.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
同類別的其他藥品
常見問題
What is Valrubicin used for?
Valrubicin is a medicine in the class oncology. It is used for Bladder cancer.
What side effects have been reported with Valrubicin?
Urinary frequency, Dysuria, Urinary urgency, Bladder spasm, Hematuria, Bladder pain.
Can Valrubicin be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm; no human data. In rats, IV valrubicin caused embryo-fetal malformations and increased resorptions. Breastfeeding: Unsafe. No data on milk presence; advise not to breastfeed during treatment and for 2 weeks after the final dose.
What does Valrubicin interact with?
MediHelp does not list a checked interaction for Valrubicin yet. Always tell your pharmacist about every medicine you take.
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