藥品參考
Topotecan
Topotecan is a medicine in the class oncology. It is used for cervical cancer.
- 藥物類別: Oncology
- 用途: cervical cancer
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Oncology
- ATC 代碼
- L01CE01
- 常見劑型
- 注射劑, 膠囊
- 常見規格
- 1 mg/ml, 4 mg
- 已知交互作用
- 110 (禁忌併用: 1 · 嚴重: 24 · 中度: 78 · 輕微: 7)
- 商品名
- 10
- 國家與市場
- 5
用途
作用方式
Binds to topoisomerase I to produce double-strand breaks in DNA
成人常用劑量（仿單摘要）
Small Cell Lung Cancer: (IV Infusion) 1.5mg/m² IV qDay x5 days; repeat at 21-day cycles,
懷孕與哺乳
- 懷孕
- Unsafe Can cause fetal harm: in rats and rabbits it caused embryo deaths and malformations (mainly eye) at about the clinical dose; no human data. Check pregnancy status; women use contraception during and for 6 months after, men for 3 months.
- 哺乳
- Unsafe No human data; rat milk levels were up to 48 times plasma levels. Do not breastfeed during treatment and for 1 week after the last dose.
已通報的副作用
- Vomiting
- Nausea
- Anemia
- Neutropenia
- Pain
- Thrombocytopenia
哪些人需要特別留意
- Fatal cases of interstitial lung disease have occurred; permanently discontinue for confirmed ILD
- If extravasation occurs, immediately stop administration and institute recommended management procedures; severe cases reported
- PO: If patient vomits after taking capsule, do NOT repeat dose
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (110)
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporin + Topotecan Major
- Cyclosporine + Topotecan Major
- Darunavir + Topotecan Major
- Deferiprone + Topotecan Major
- Dengue vaccine + Topotecan Major
- Etrasimod + Topotecan Major
同類別的其他藥品
常見問題
What is Topotecan used for?
Topotecan is a medicine in the class oncology. It is used for Cervical cancer, Lung cancer, Ovarian cancer.
What side effects have been reported with Topotecan?
Vomiting, Nausea, Anemia, Neutropenia, Pain, Thrombocytopenia.
Can Topotecan be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: in rats and rabbits it caused embryo deaths and malformations (mainly eye) at about the clinical dose; no human data. Check pregnancy status; women use contraception during and for 6 months after, men for 3 months. Breastfeeding: Unsafe. No human data; rat milk levels were up to 48 times plasma levels. Do not breastfeed during treatment and for 1 week after the last dose.
What does Topotecan interact with?
MediHelp lists 110 known interactions for Topotecan. Contraindicated: 1 · Major: 24 · Moderate: 78 · Minor: 7. The most serious include Adenovirus types 4 and 7 live, Amiodarone, Cisplatin.
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