藥品參考
Irinotecan
Irinotecan is a medicine in the class oncology. It is used for colorectal cancer.
- 藥物類別: Oncology
- 用途: colorectal cancer
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Oncology
- ATC 代碼
- L01CE02
- 常見劑型
- 注射劑, 輸注液
- 常見規格
- 40 mg/2 ml, 20 mg/ml, 100 mg/5 ml
- 已知交互作用
- 174 (禁忌併用: 2 · 嚴重: 49 · 中度: 93 · 輕微: 30)
- 商品名
- 25
- 國家與市場
- 5
用途
作用方式
Binds to topoisomerase I to produce double-strand breaks in DNA
成人常用劑量（仿單摘要）
Regimen 1 (Weekly): 125 mg/m² IV infusion over 90 minutes on days 1, 8, 15, 22, then 2 weeks off, then repeat
懷孕與哺乳
- 懷孕
- Unsafe Can cause fetal harm: embryo deaths and birth defects in rats and rabbits below human exposure; human data are limited. Avoid; verify pregnancy status. Contraception after the last dose: women 6 months, men 3 months (liposomal form: 7 and 4 months).
- 哺乳
- Unsafe Irinotecan and its active metabolite pass into milk, the metabolite for up to a week after a dose. US labels: do not breastfeed during treatment and for 7 days after the last dose (liposomal form: 1 month). LactMed: higher doses may need a longer break.
已通報的副作用
- Diarrhea
- Nausea
- Leukopenia
- Anemia
- Neutropenia
- Thrombocytopenia
哪些人需要特別留意
- Drug is subject to photodegradation, especially in neutral and alkaline solutions
- Avoid pregnancy; can cause fetal harm
- Renal impairment and acute renal failure reported; usually in patients who became volume depleted from severe vomiting and/or diarrhea
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (174)
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
- Clarithromycin + Irinotecan Major
- Cobicistat + Irinotecan Major
- Conivaptan + Irinotecan Major
- Cyclosporin + Irinotecan Major
同類別的其他藥品
常見問題
What is Irinotecan used for?
Irinotecan is a medicine in the class oncology. It is used for Colorectal cancer.
What side effects have been reported with Irinotecan?
Diarrhea, Nausea, Leukopenia, Anemia, Neutropenia, Thrombocytopenia.
Can Irinotecan be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: embryo deaths and birth defects in rats and rabbits below human exposure; human data are limited. Avoid; verify pregnancy status. Contraception after the last dose: women 6 months, men 3 months (liposomal form: 7 and 4 months). Breastfeeding: Unsafe. Irinotecan and its active metabolite pass into milk, the metabolite for up to a week after a dose. US labels: do not breastfeed during treatment and for 7 days after the last dose (liposomal form: 1 month). LactMed: higher doses may need a longer break.
What does Irinotecan interact with?
MediHelp lists 174 known interactions for Irinotecan. Contraindicated: 2 · Major: 49 · Moderate: 93 · Minor: 30. The most serious include Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
