跳至主要內容
MediHelp
MediHelp 藥品參考

藥品參考

Vandetanib

Vandetanib is a medicine in the class oncology. It is used for thyroid cancer.

最後更新 來源: US FDA label

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

重點資訊

藥物類別
Oncology
常見劑型
錠劑
已知交互作用
137 (禁忌併用: 42 · 嚴重: 71 · 中度: 20 · 輕微: 4)
商品名
2
國家與市場
2

劑型、規格與商品名稱會因國家而異。請核對您手上的產品。

用途

作用方式

Vandetanib inhibits the tyrosine kinase activity of the EGFR and VEGFR families, RET, BRK, TIE2, and members of the EPH receptor and Src kinase families.

成人常用劑量（仿單摘要）

Medullary thyroid cancer (symptomatic or progressive, unresectable locally advanced or metastatic): 300 mg orally once daily until disease progression or unacceptable toxicity

僅摘錄仿單中第一行劑量說明；完整的劑量內容請見 App。

懷孕與哺乳

懷孕
Unsafe Can cause fetal harm; no human data. Embryotoxic, fetotoxic and caused fetal malformations in rats. Verify pregnancy status before starting and use effective contraception.
哺乳
Unsafe No human milk data; present in rat milk. Advise not to breastfeed during treatment and for 4 months after the last dose.

已通報的副作用

  • Diarrhea/colitis
  • Rash
  • Acneiform dermatitis
  • Hypertension
  • Nausea
  • Headache

黑框警語

  • Can prolong the QT interval; torsades de pointes and sudden death have occurred. Do not use in patients with hypocalcemia, hypokalemia, hypomagnesemia, or long QT syndrome. Correct hypocalcemia, hypokalemia and/or hypomagnesemia before administration, monitor electrolytes periodically, and avoid drugs known to prolong the QT interval.

禁忌症

  • Congenital long QT syndrome

哪些人需要特別留意

  • QT prolongation: do not start if QTcF >450 ms; obtain ECG and potassium, calcium, magnesium and TSH at baseline, 2 to 4 weeks, 8 to 12 weeks, then every 3 months.
  • Severe, sometimes fatal skin reactions including TEN and Stevens-Johnson syndrome; permanently discontinue for severe reactions. Photosensitivity can occur up to 4 months after discontinuation.
  • Interstitial lung disease/pneumonitis, including fatalities; discontinue if confirmed.

請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。

重要交互作用 (137)

All 137 interactions, with severity and what to do

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可開啟 Vandetanib 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。

  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Dosing in older adults
  • How to give it
  • Pharmacokinetics
  • Patient counselling points
  • Food interactions
  • IV preparation and dilution
建立免費帳號 登入

在網頁版免費試用 Pro+ 14 天，無需信用卡。

同類別的其他藥品

常見問題

What is Vandetanib used for?

Vandetanib is a medicine in the class oncology. It is used for Thyroid cancer.

What side effects have been reported with Vandetanib?

Diarrhea/colitis, Rash, Acneiform dermatitis, Hypertension, Nausea, Headache. Serious warning: Can prolong the QT interval; torsades de pointes and sudden death have occurred.

Can Vandetanib be taken in pregnancy or while breastfeeding?

Pregnancy: Unsafe. Can cause fetal harm; no human data. Embryotoxic, fetotoxic and caused fetal malformations in rats. Verify pregnancy status before starting and use effective contraception. Breastfeeding: Unsafe. No human milk data; present in rat milk. Advise not to breastfeed during treatment and for 4 months after the last dose.

What does Vandetanib interact with?

MediHelp lists 137 known interactions for Vandetanib. Contraindicated: 42 · Major: 71 · Moderate: 20 · Minor: 4. The most serious include Amiodarone, Amisulpride, Amitriptyline.

在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查

在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。

下載於App Store 立即下載Google Play

依 A–Z 瀏覽 · 藥品參考

取得 App 登入