藥物交互作用
Amiodarone + Vandetanib
嚴重程度: 禁忌併用
Amiodarone and Vandetanib: contraindicated interaction.
最後更新
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摘要
Vandetanib markedly prolongs the QT interval and its labeling advises avoiding other QT-prolonging drugs. With amiodarone, whose half-life is very long, the risk of torsades de pointes and sudden death is significantly increased.
用白話說明這項交互作用的意義
Amiodarone and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amiodarone belongs to Cardiovascular; Vandetanib belongs to Oncology.
為什麼會發生
Additive QT prolongation through repolarizing potassium channel blockade.
處置方式
Avoid the combination and choose an alternative therapy. Do not start vandetanib while amiodarone is still present in the body unless benefits clearly outweigh risks, with close ECG and electrolyte monitoring.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Amiodarone 的其他交互作用
Vandetanib 的其他交互作用
常見問題
Can I take Amiodarone with Vandetanib?
MediHelp rates the interaction as contraindicated. Amiodarone and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib markedly prolongs the QT interval and its labeling advises avoiding other QT-prolonging drugs. With amiodarone, whose half-life is very long, the risk of torsades de pointes and sudden death is significantly increased.
How serious is the interaction between Amiodarone and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative therapy. Do not start vandetanib while amiodarone is still present in the body unless benefits clearly outweigh risks, with close ECG and electrolyte monitoring.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
