藥物交互作用
Amitriptyline + Vandetanib
嚴重程度: 禁忌併用
Amitriptyline and Vandetanib: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Vandetanib markedly prolongs the QT interval and has been associated with torsades de pointes and sudden death. Adding amitriptyline, which also prolongs QT, increases that risk further.
用白話說明這項交互作用的意義
Amitriptyline and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amitriptyline belongs to Central Nervous System; Vandetanib belongs to Oncology.
為什麼會發生
Additive QT prolongation through cardiac potassium channel effects.
處置方式
Avoid the combination and choose a non-QT-prolonging antidepressant. If a QT-prolonging drug cannot be avoided, use intensive ECG and electrolyte monitoring.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Amitriptyline 的其他交互作用
Vandetanib 的其他交互作用
常見問題
Can I take Amitriptyline with Vandetanib?
MediHelp rates the interaction as contraindicated. Amitriptyline and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib markedly prolongs the QT interval and has been associated with torsades de pointes and sudden death. Adding amitriptyline, which also prolongs QT, increases that risk further.
How serious is the interaction between Amitriptyline and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antidepressant. If a QT-prolonging drug cannot be avoided, use intensive ECG and electrolyte monitoring.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
