藥物交互作用
Cilostazol + Vonoprazan
嚴重程度: 中度
Cilostazol and Vonoprazan: moderate interaction.
最後更新
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摘要
Vonoprazan may increase cilostazol exposure through effects on CYP2C19 and CYP3A4, which could increase cilostazol adverse effects such as headache and tachycardia.
用白話說明這項交互作用的意義
Cilostazol and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Vonoprazan belongs to Gastrointestinal Tract.
為什麼會發生
Vonoprazan may inhibit CYP2C19 and CYP3A4 metabolism of cilostazol.
處置方式
Consider reducing cilostazol to 50 mg twice daily during co-administration. Monitor heart rate and tolerability.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cilostazol 的其他交互作用
Vonoprazan 的其他交互作用
常見問題
Can I take Cilostazol with Vonoprazan?
MediHelp rates the interaction as moderate. Cilostazol and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan may increase cilostazol exposure through effects on CYP2C19 and CYP3A4, which could increase cilostazol adverse effects such as headache and tachycardia.
How serious is the interaction between Cilostazol and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing cilostazol to 50 mg twice daily during co-administration. Monitor heart rate and tolerability.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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