藥物交互作用
Chlordiazepoxide + Zuranolone
嚴重程度: 嚴重
Chlordiazepoxide and Zuranolone: major interaction.
最後更新
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摘要
Zuranolone causes CNS depression and impairs driving and psychomotor performance. Adding chlordiazepoxide increases the risk of excessive sedation and impairment.
用白話說明這項交互作用的意義
Chlordiazepoxide and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
為什麼會發生
Additive CNS depression via positive allosteric modulation of GABA-A receptors by both drugs.
處置方式
Avoid the combination where possible; if required, consider reducing the zuranolone dose and monitor for sedation. Counsel patients not to drive or operate machinery.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlordiazepoxide 的其他交互作用
Zuranolone 的其他交互作用
常見問題
Can I take Chlordiazepoxide with Zuranolone?
MediHelp rates the interaction as major. Chlordiazepoxide and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Zuranolone causes CNS depression and impairs driving and psychomotor performance. Adding chlordiazepoxide increases the risk of excessive sedation and impairment.
How serious is the interaction between Chlordiazepoxide and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if required, consider reducing the zuranolone dose and monitor for sedation. Counsel patients not to drive or operate machinery.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
