藥物交互作用
Abatacept + Tofacitinib
嚴重程度: 嚴重
Abatacept and Tofacitinib: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Tofacitinib is not recommended with biologic DMARDs because of increased risk of serious infection. Abatacept adds overlapping T-cell suppression.
用白話說明這項交互作用的意義
Abatacept and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Abatacept belongs to Musculoskeletal; Tofacitinib belongs to Musculoskeletal.
為什麼會發生
Additive immunosuppression via JAK inhibition and T-cell costimulation blockade.
處置方式
Avoid combined use; choose one agent and monitor for infection when changing therapy.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Abatacept 的其他交互作用
Tofacitinib 的其他交互作用
常見問題
Can I take Abatacept with Tofacitinib?
MediHelp rates the interaction as major. Abatacept and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tofacitinib is not recommended with biologic DMARDs because of increased risk of serious infection. Abatacept adds overlapping T-cell suppression.
How serious is the interaction between Abatacept and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use; choose one agent and monitor for infection when changing therapy.
What other medicines interact with Abatacept?
MediHelp also lists interactions of Abatacept with, for example, Adalimumab, Adenovirus types 4 and 7 live, Anakinra. The full list is on the Abatacept page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
