藥物交互作用
Tofacitinib + Upadacitinib
嚴重程度: 禁忌併用
Tofacitinib and Upadacitinib: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Two JAK inhibitors together duplicate pharmacology and give additive immunosuppression, increasing the risk of serious infection, cytopenias and other class adverse effects. There is no evidence of benefit from combining them.
用白話說明這項交互作用的意義
Tofacitinib and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Tofacitinib belongs to Musculoskeletal; Upadacitinib belongs to Musculoskeletal.
為什麼會發生
Duplicate JAK inhibition leads to additive immunosuppression.
處置方式
Do not use together; use one JAK inhibitor only, and stop the first before starting the other.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Tofacitinib 的其他交互作用
Upadacitinib 的其他交互作用
常見問題
Can I take Tofacitinib with Upadacitinib?
MediHelp rates the interaction as contraindicated. Tofacitinib and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Two JAK inhibitors together duplicate pharmacology and give additive immunosuppression, increasing the risk of serious infection, cytopenias and other class adverse effects. There is no evidence of benefit from combining them.
How serious is the interaction between Tofacitinib and Upadacitinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; use one JAK inhibitor only, and stop the first before starting the other.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Abatacept. The full list is on the Tofacitinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
