藥物交互作用
Cladribine + Tofacitinib
嚴重程度: 禁忌併用
Cladribine and Tofacitinib: contraindicated interaction.
最後更新
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摘要
Cladribine causes prolonged lymphopenia, and tofacitinib adds immunosuppression, markedly increasing the risk of serious infection. Oral cladribine labeling advises against combination with immunosuppressive therapies.
用白話說明這項交互作用的意義
Cladribine and Tofacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cladribine belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
為什麼會發生
Additive lymphocyte depletion and immunosuppression.
處置方式
Do not combine; avoid tofacitinib during and after cladribine courses while lymphopenia persists. Select alternative therapy and monitor lymphocyte counts.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Tofacitinib 的其他交互作用
Cladribine 的其他交互作用
常見問題
Can I take Cladribine with Tofacitinib?
MediHelp rates the interaction as contraindicated. Cladribine and Tofacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cladribine causes prolonged lymphopenia, and tofacitinib adds immunosuppression, markedly increasing the risk of serious infection. Oral cladribine labeling advises against combination with immunosuppressive therapies.
How serious is the interaction between Cladribine and Tofacitinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; avoid tofacitinib during and after cladribine courses while lymphopenia persists. Select alternative therapy and monitor lymphocyte counts.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Upadacitinib, Abatacept. The full list is on the Tofacitinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
