藥物交互作用
Abiraterone + Rifapentine
嚴重程度: 嚴重
Abiraterone and Rifapentine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Rifapentine induces CYP3A4 and is expected to lower abiraterone concentrations. This could reduce its effectiveness against prostate cancer.
用白話說明這項交互作用的意義
Abiraterone and Rifapentine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Abiraterone belongs to Endocrine; Rifapentine belongs to Anti Bacterial.
為什麼會發生
Rifapentine induces CYP3A4, accelerating abiraterone metabolism.
處置方式
Avoid if possible. If required, increase abiraterone to twice daily during rifapentine therapy and monitor PSA and clinical response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Abiraterone 的其他交互作用
Rifapentine 的其他交互作用
常見問題
Can I take Abiraterone with Rifapentine?
MediHelp rates the interaction as major. Abiraterone and Rifapentine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifapentine induces CYP3A4 and is expected to lower abiraterone concentrations. This could reduce its effectiveness against prostate cancer.
How serious is the interaction between Abiraterone and Rifapentine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If required, increase abiraterone to twice daily during rifapentine therapy and monitor PSA and clinical response.
What other medicines interact with Abiraterone?
MediHelp also lists interactions of Abiraterone with, for example, Radium-223 dichloride, Thioridazine, Amobarbital. The full list is on the Abiraterone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
