藥物交互作用
Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir
嚴重程度: 禁忌併用
Rifapentine and Sofosbuvir-velpatasvir-voxilaprevir: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Rifapentine is an inducer of CYP enzymes and P-glycoprotein and can markedly lower plasma concentrations of sofosbuvir, velpatasvir and voxilaprevir. This may lead to loss of antiviral activity and failure to achieve sustained virologic response.
用白話說明這項交互作用的意義
Rifapentine and Sofosbuvir-velpatasvir-voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Rifapentine belongs to Anti Bacterial; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
為什麼會發生
Induction of intestinal and hepatic CYP3A4 and P-glycoprotein by rifapentine increases clearance and reduces absorption of the HCV agents.
處置方式
Do not coadminister; rifamycin inducers are not recommended with this regimen. Choose an alternative tuberculosis regimen or delay HCV therapy until rifapentine is completed.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Sofosbuvir-velpatasvir-voxilaprevir 的其他交互作用
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir 禁忌併用
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir 禁忌併用
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir 禁忌併用
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir 禁忌併用
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir 禁忌併用
- Sofosbuvir-velpatasvir-voxilaprevir + St john's wort 禁忌併用
Rifapentine 的其他交互作用
常見問題
Can I take Rifapentine with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as contraindicated. Rifapentine and Sofosbuvir-velpatasvir-voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifapentine is an inducer of CYP enzymes and P-glycoprotein and can markedly lower plasma concentrations of sofosbuvir, velpatasvir and voxilaprevir. This may lead to loss of antiviral activity and failure to achieve sustained virologic response.
How serious is the interaction between Rifapentine and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; rifamycin inducers are not recommended with this regimen. Choose an alternative tuberculosis regimen or delay HCV therapy until rifapentine is completed.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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