藥物交互作用
Lurasidone + Rifapentine
嚴重程度: 禁忌併用
Lurasidone and Rifapentine: contraindicated interaction.
最後更新
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摘要
Rifapentine induces CYP3A4 and can substantially lower lurasidone exposure. This may cause loss of antipsychotic efficacy and relapse. Strong CYP3A4 inducers are contraindicated with lurasidone.
用白話說明這項交互作用的意義
Lurasidone and Rifapentine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lurasidone belongs to Central Nervous System; Rifapentine belongs to Anti Bacterial.
為什麼會發生
Induction of CYP3A4 increases lurasidone clearance.
處置方式
Avoid the combination; if rifapentine is required, use an antipsychotic less dependent on CYP3A4 and monitor psychiatric status.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Lurasidone 的其他交互作用
Rifapentine 的其他交互作用
常見問題
Can I take Lurasidone with Rifapentine?
MediHelp rates the interaction as contraindicated. Lurasidone and Rifapentine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifapentine induces CYP3A4 and can substantially lower lurasidone exposure. This may cause loss of antipsychotic efficacy and relapse. Strong CYP3A4 inducers are contraindicated with lurasidone.
How serious is the interaction between Lurasidone and Rifapentine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if rifapentine is required, use an antipsychotic less dependent on CYP3A4 and monitor psychiatric status.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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