藥物交互作用
Acalabrutinib + Calcium
嚴重程度: 中度
Acalabrutinib and Calcium: moderate interaction.
最後更新
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摘要
Acalabrutinib capsules need an acidic stomach for dissolution, and calcium carbonate antacids raise gastric pH. Exposure and efficacy may fall.
用白話說明這項交互作用的意義
Acalabrutinib and Calcium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acalabrutinib belongs to Oncology; Calcium belongs to Gastrointestinal Tract.
為什麼會發生
Antacid-induced rise in gastric pH reduces the solubility and absorption of acalabrutinib.
處置方式
Give calcium carbonate antacids at least 2 hours apart from acalabrutinib capsules. Tablet formulations are not affected by gastric pH.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Calcium 的其他交互作用
Acalabrutinib 的其他交互作用
常見問題
Can I take Acalabrutinib with Calcium?
MediHelp rates the interaction as moderate. Acalabrutinib and Calcium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Acalabrutinib capsules need an acidic stomach for dissolution, and calcium carbonate antacids raise gastric pH. Exposure and efficacy may fall.
How serious is the interaction between Acalabrutinib and Calcium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give calcium carbonate antacids at least 2 hours apart from acalabrutinib capsules. Tablet formulations are not affected by gastric pH.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Alendronate, Atazanavir. The full list is on the Calcium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
