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藥物交互作用

Alendronate + Calcium

嚴重程度: 中度

Alendronate and Calcium: moderate interaction.

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僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Oral calcium binds alendronate in the gut and markedly reduces its absorption. This can make the bisphosphonate less effective for osteoporosis.

用白話說明這項交互作用的意義

Alendronate and Calcium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Alendronate belongs to Musculoskeletal; Calcium belongs to Gastrointestinal Tract.

證據等級: High

為什麼會發生

Chelation of alendronate by calcium cations in the gastrointestinal tract reduces absorption.

處置方式

Take alendronate first with plain water on an empty stomach and wait at least 30 minutes before any calcium, food or other drinks.

可向藥師詢問的問題

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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常見問題

Can I take Alendronate with Calcium?

MediHelp rates the interaction as moderate. Alendronate and Calcium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium binds alendronate in the gut and markedly reduces its absorption. This can make the bisphosphonate less effective for osteoporosis.

How serious is the interaction between Alendronate and Calcium?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take alendronate first with plain water on an empty stomach and wait at least 30 minutes before any calcium, food or other drinks.

What other medicines interact with Calcium?

MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Atazanavir. The full list is on the Calcium page.

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