藥物交互作用
Acalabrutinib + Pantoprazole
嚴重程度: 嚴重
Acalabrutinib and Pantoprazole: major interaction.
最後更新
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摘要
Acalabrutinib capsules need an acidic stomach to dissolve, and pantoprazole's prolonged acid suppression can lower acalabrutinib absorption. This may reduce efficacy.
用白話說明這項交互作用的意義
Acalabrutinib and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acalabrutinib belongs to Oncology; Pantoprazole belongs to Gastrointestinal Tract.
為什麼會發生
Increased gastric pH from the proton pump inhibitor reduces dissolution and absorption of acalabrutinib capsules.
處置方式
Avoid pantoprazole; use the acalabrutinib tablet formulation, which is not pH-dependent, or switch to an alternative acid-reducing approach with appropriate timing.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pantoprazole 的其他交互作用
Acalabrutinib 的其他交互作用
常見問題
Can I take Acalabrutinib with Pantoprazole?
MediHelp rates the interaction as major. Acalabrutinib and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Acalabrutinib capsules need an acidic stomach to dissolve, and pantoprazole's prolonged acid suppression can lower acalabrutinib absorption. This may reduce efficacy.
How serious is the interaction between Acalabrutinib and Pantoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pantoprazole; use the acalabrutinib tablet formulation, which is not pH-dependent, or switch to an alternative acid-reducing approach with appropriate timing.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Atazanavir, Dacomitinib. The full list is on the Pantoprazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
